Highlighted Publications
Selected publications emphasized in the source list, spanning perianal Crohn's disease, translational science, and COVID-19/IBD research.
Impact of Crohn's perianal fistulas on healthcare resource utilization: a US chart review study
Deepak P, Wong SY, Parian AM, Sun M, Nazarey P, Cazzetta S, Terreri B, Turner B, Goodwin B · J Med Econ · 2026
A U.S. chart review examining how perianal fistulas in Crohn's disease affect healthcare use, including the burden of visits, procedures, and ongoing care.
View PublicationTherapeutic Benefit of Upadacitinib in Severe Post-Proctectomy (Class 4) Perianal Crohn's Disease: A Three-Patient Case Series
Hanna LN, Quraishi B, Pelly T, Lung P, Tozer P, Hart A, Wong SY, Powell N · Inflamm Bowel Dis · 2026
A three-patient case series describing the use of upadacitinib in severe post-proctectomy (Class 4) perianal Crohn's disease and the clinical benefit observed in these difficult cases.
View PublicationReal-World Effectiveness of Upadacitinib for Perianal Crohn's Disease: A Multicenter Retrospective Study
Devi J, Patel A, Quraishi B, Dev B, Tan T, Kline M, Chowla N, Ramesh PR, Ballard DH, Huang L, Jaiprada F, Samaan S, Stone M, Khan A, Seeraj AA, Alanazi S, Xu A, Maas L, Jajoo A, Parian A, Altinmakas E, Ehman EC, Davenport MS, Li S, Chithriki M, Shukla R, McCurdy J, Yarur AJ, Bishu S, Johnson AM, Benjamin M, Dulaney D, Serre-Yu W, Deepak P · Clin Gastroenterol Hepatol · 2026
A multicenter retrospective study evaluating how well upadacitinib works for perianal Crohn's disease in real-world clinical practice.
View PublicationTunnel vision: rethinking local therapy for perianal fistulas in Crohn's disease
Estevinho MM, Shakweh E, Cho W, Rozenberg F, Hanna L, Khaitov S, Colombel JF, Powell N, Faith J, Wong SY · J Crohns Colitis · 2026
A review that shifts attention toward the fistula tract itself and the potential role of local therapy alongside systemic treatment for Crohn's disease.
View PublicationInvisible Burdens: The Influence of Stigma and Social Determinants on Quality of Life in Perianal Fistulizing Crohn's Disease
Shenoy S, Debroff J, Lacoste J, Giselbrecht E, Gbenebitse NO, Llona R, Moran HR, Rozenberg F, Keefer L, Wong SY · J Clin Gastroenterol · 2025
An examination of how stigma and social determinants of health affect quality of life for people living with perianal fistulizing Crohn's disease.
View PublicationUnderstanding Pouch-Related Fistulae: Don't Lose Track of Time
Bronze S, Wong SY, Waite H, Khaitov S, Plietz M, Hahn S, Greenstein A, Sylla P, Colombel JF, Kayal M · Inflamm Bowel Dis · 2025
A focused discussion of pouch-related fistulas that emphasizes the importance of timing and clinical context when determining why a fistula developed and how it should be managed.
View PublicationIleoanal Pouch-Related Fistulas: A Narrative Review
Bronze S, Kayal M, Estevinho MM, Hahn S, Khaitov S, Colombel JF, Wong SY · Inflamm Bowel Dis · 2025
A narrative review covering the causes, evaluation, and management of fistulas that develop in patients with an ileoanal pouch.
View PublicationPerianal Fistulizing Crohn's Disease-Associated Anorectal and Fistula Cancers: Systematic Review and Expert Consensus
Wong SY, Rowan C, Brockmans ED, Law CCY, Giselbrecht E, Ang C, Khaitov S, Sachar D, Polydorides AD, Winata LS, Verstockt B, Spinelli A, Rubin DT, Deepak P, McGovern DPB, McDonald BD, Lung P, Lundby L, Lightner AL, Holubar SD, Hanna L, Hamarth C, Geldof J, Dige A, Cohen BL, Carvello M, Bonifacio C, Bislenghi G, Behrenbruch C, Ballard DH, Altinmakas E, Sebastian S, Tozer P, Hart A, Colombel JF · Clin Gastroenterol Hepatol · 2025
A systematic review and expert consensus on anorectal and fistula-associated cancers in perianal Crohn's disease, including recognition, surveillance, and management of these rare complications.
View PublicationNatural History of Clinically Suspected Isolated Perianal Fistulizing Crohn's Disease
Sangmo L, Quraishi B, Rajauria P, Giselbrecht E, Colombel JF, Ungaro R, Wong SY · Clin Gastroenterol Hepatol · 2025
A study describing the natural history of patients with clinically suspected isolated perianal fistulizing Crohn's disease and how the condition evolves over time.
View PublicationGoblet Cell Loss Linked to NOD2 and Secondary Resection in Crohn's Disease Is Induced by Dysbiosis and Epithelial MyD88
Wong SY, Estevinho MM, Heaney T, Marshall AA, Giselbrecht E, Daniel SG, Zhou C, Rosas-Villegas A, Jang KK, Yang H, Ko HM, Paulsen JD, Ding Y, Bittinger K, Cho JH, Lewis JD, Ramanan D, Cadwell K · Cell Mol Gastroenterol Hepatol · 2025
A mechanistic study linking Crohn's-associated goblet cell loss to NOD2, dysbiosis, and epithelial MyD88 signaling, with implications for patients who require repeat intestinal resection.
View PublicationAntibody, not Cellular, Immune Responses to SARS-CoV-2 Vaccination Outperform Infection in Inflammatory Bowel Disease Patients
González Cueto E, Edmans M, Wellens J, Cadwell K, Thompson C, Satsangi J, Wong SY; ICARUS-IBD working group · Inflamm Bowel Dis · 2024
A study comparing immune responses to SARS-CoV-2 infection and vaccination in patients with inflammatory bowel disease, with antibody responses after vaccination standing out as particularly strong.
View PublicationCytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab
Dallari S, Martinez Pazos V, Munoz Eusse J, Wellens J, Thompson C, Colombel JF, Satsangi J, Cadwell K, Wong SY; ICARUS-IBD Working Group · Sci Rep · 2024
A study characterizing the cytokine profile of patients with inflammatory bowel disease receiving vedolizumab after recovery from SARS-CoV-2 infection.
View PublicationGeography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium
Wong SY, Wellens J, Helmus D, Marlow L, Brann S, Martinez Pazos V, Weinberg A, Moran HR, McGregor C, Vermeire S, Watanabe K, Kamikozuru K, Ahuja V, Vermani S, Lindsay JO, Kingston A, Dutta U, Kaur H, Silverberg MS, Milgrom R, Chien Ng S, Mak JWY, Cadwell K, Thompson C, Colombel JF, Satsangi J; ICARUS-IBD Consortium · Inflamm Bowel Dis · 2023
A multinational analysis from the ICARUS-IBD consortium examining how geography is associated with differences in SARS-CoV-2 serologic responses among patients with inflammatory bowel disease.
View PublicationSerologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies
Wong SY, Dixon R, Martinez Pazos V, Gnjatic S, Colombel JF, Cadwell K; ICARUS-IBD Working Group · Gastroenterology · 2019
An early study measuring antibody responses to mRNA COVID-19 vaccines in patients with inflammatory bowel disease receiving biologic therapies.
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