Clinical
Clinical research on diagnosis, classification, treatment, imaging, surgery, outcomes, and complications of perianal and related Crohn's disease.
Systematic Review of Published Guidelines: Recommendations for Exams Under Anaesthesia, Seton Insertion and Timing of Seton Removal for Perianal and Rectovaginal Fistulising Crohn's Disease
Medawar E, Chaudhary H, Zoughlami A, Ekhdoura M, Safih W, Gupta S, Wong SY, Deepak P, Hart A, Tozer P, McCurdy JD · Aliment Pharmacol Ther · 2026
A systematic review comparing published guidelines on exam under anesthesia, seton placement, and when setons should be removed in perianal and rectovaginal fistulizing Crohn's disease.
View PublicationFistula Outcomes After Seton Removal in Patients with Perianal Fistulizing Crohn's Disease: A Systematic Review and Meta-Analysis
Medawar E, Chin Koon Siw K, Zoughlami A, Ekhdoura M, Safih W, Gupta S, Wong SY, Deepak P, Parian AM, Kotze PG, McCurdy JD · Dig Dis Sci · 2026
A systematic review and meta-analysis summarizing fistula outcomes after seton removal in perianal fistulizing Crohn's disease, helping frame expectations for healing and recurrence.
View PublicationDefining Radiological Healing in Perianal Fistulizing Crohn's Disease: A TOpClass Global Expert Delphi Consensus
Anand E, Devi J, Ballard DH, Joshi S, Tozer P, Hart A, Antoniou A, Deepak P, Stoker J, Lung P; TOpClass collaborative authors · Clin Gastroenterol Hepatol · 2026
A global expert Delphi consensus aimed at standardizing what radiological healing should mean on imaging in perianal fistulizing Crohn's disease.
View PublicationIsolated perianal Crohn's disease: a systematic review and expert consensus proposing novel diagnostic criteria and management advice
Hanna LN, Munster LJ, Joshi S, Wendelien van der Bilt JD, Buskens CJ, Hart A, Tozer P; TOpClass Collaborators · Lancet Gastroenterol Hepatol · 2025
A systematic review and expert consensus proposing diagnostic criteria and management guidance for isolated perianal Crohn's disease, where luminal disease may be absent.
View PublicationA Guide Through the Tunnel: Updates in the Approach to Classification and Management of Perianal Fistulizing Crohn's Disease
Cho WJ, Wong SY · Curr Gastroenterol Rep · 2025
A practical update on how perianal fistulizing Crohn's disease is classified and managed, with a focus on applying newer frameworks to clinical care.
View PublicationDelphi Panel for the Development of Diagnostic Criteria for Metastatic Cutaneous Crohn Disease: A Consensus Statement
Ebriani J, Santiago-Soltero K, Anshelevich EE, Dalal RS, Shields B, Charrow A; Metastatic Cutaneous Crohn’s Disease Delphi Panel; Agrawal M, Alavi A, Burgin S, Cices A, Coromilas AJ, Cowen EW, Goldfarb N, Hsiao JL, McGee JS, Ortega- Loayza AG, Porter M, Rosenbach M, Shaw KS, Wanat KA, Watson AJ, Wong SY · JAMA Dermatol · 2025
An expert consensus statement establishing diagnostic criteria for metastatic cutaneous Crohn disease, a rare form of Crohn's involving skin away from the gastrointestinal tract.
View PublicationPerianal Fistulizing Crohn's Disease: Utilizing the TOpClass Classification in Clinical Practice to Provide Targeted Individualized Care
Hanna LN, Anandabaskaran S, Iqbal N, Geldof J, LeBlanc JF, Dige A, Lundby L, Vermeire S, D'Hoore A, Verstockt B, Bislenghi G, De Looze D, Lobaton T, Van de Putte D, Spinelli A, Carvello M, Danese S, Buskens CJ, Gecse K, Hompes R, Becker M, van der Bilt J, Bemelman W, Sebastian S, Moran G, Lightner AL, Wong SY, Colombel JF, Cohen BL, Holubar SD, Ding NS, Behrenbruch C, Sahnan K, Misra R, Lung P, Hart A, Tozer P · Clin Gastroenterol Hepatol · 2025
A clinical review showing how the TOpClass system can be used to sort perianal fistulizing Crohn's disease into meaningful groups and tailor care to the individual patient.
View PublicationTOpClass Class 4 Perineal Crohn's Disease: A Systematic Review and Meta-analysis of Perineal Wound Complication After Proctectomy in Crohn's Patients
Alipouriani A, Erozkan K, Schabl L, Sancheti H, Sebastian S, Wong SY, Tozer P, Cohen BL, Holubar SD · Inflamm Bowel Dis · 2025
A systematic review and meta-analysis examining perineal wound complications after proctectomy in patients with severe Class 4 perineal Crohn's disease.
View PublicationDiagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB)
Munster LJ, Hanna LN, Hart AL, Tozer PJ, Buskens CJ, van der Bilt JDW; TOpCLASS perianal Crohn’s disease Consortium, the Dutch Initiative on Crohn and Colitis (ICC) and the Initiative on Crohn and Colitis - Surgery (ICC-S) · J Crohns Colitis · 2025
An expert Delphi consensus identifying features that should raise concern for Crohn's disease in patients who initially appear to have a cryptoglandular perianal fistula.
View PublicationEditorial: Mesenchymal Stem Cell Therapy for Perianal Fistulising Crohn's DiseaseEffective or Hype?
McCurdy JD, Wong SY · Aliment Pharmacol Ther · 2025
An editorial weighing the evidence for mesenchymal stem cell therapy in perianal fistulizing Crohn's disease and asking whether the clinical enthusiasm is fully supported by the data.
View PublicationCancer Screening in Patients With Inflammatory Bowel Disease: Don't Forget the Anus!
Wong SY, Colombel JF · Inflamm Bowel Dis · 2024
A short clinical commentary emphasizing that cancer surveillance in inflammatory bowel disease should include attention to the anus, not only the colon.
View PublicationProblem with Hookups: Perianal Fistula After Ileal Pouch-Anal Anastomosis
Djalal A, Wong SY, Colombel JF, Ungaro R, Kayal M · Dig Dis Sci · 2024
A clinical discussion of perianal fistula after ileal pouch-anal anastomosis and the diagnostic and management questions that arise in this setting.
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