Basic Science
Mechanistic research on epithelial biology, microbes, immune signaling, genetics, and DNA repair.
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome
Dallari S, Heaney T, Rosas-Villegas A, Neil JA, Wong SY, Brown JJ, Urbanek K, Herrmann C, Depledge DP, Dermody TS, Cadwell K · Cell Host Microbe · 2021
A basic-science study showing that enteric viruses can trigger broad host immune responses that resemble responses usually associated with the bacterial microbiome.
View PublicationThere was collusion: Microbes in inflammatory bowel disease
Wong SY, Cadwell K · PLoS Pathog · 2018
A review of how microbes and host biology interact in inflammatory bowel disease, emphasizing that disease can emerge from combined effects rather than a single microbial culprit.
View PublicationB Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains
Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K · J Immunol · 2018
A mouse-model study showing that B-cell abnormalities attributed to Nod2 deficiency can actually result from a linked Dock2 mutation, underscoring the importance of genetic background in experimental models.
View PublicationA RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction
Wong SY, Lu CP, Roth DB · J Immunol · 2008
A mechanistic study of a RAG1 mutation found in Omenn syndrome, showing how altered DNA processing can restrict the diversity of the antigen receptor repertoire.
View PublicationRag mutations reveal robust alternative end joining
Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB · Nature · 2007
A study demonstrating that RAG mutations can reveal a robust alternative pathway for joining DNA ends when normal V(D)J recombination is disrupted.
View PublicationMurine models of Omenn syndrome
Wong SY, Roth DB · J Clin Invest · 2007
A review of mouse models of Omenn syndrome and what they reveal about the immune and genetic mechanisms that produce the disease.
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